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      2. Transduced adult stem cells into in

        時間:2024-05-20 06:01:37 臨床醫學畢業論文 我要投稿
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        Transduced adult stem cells into in

        畢業論文


        全部作者:楊川 程樺 李焱 劉丹 王川 嚴勵 傅祖植
        第1作者單位:中山大學附屬第2醫院內分泌科
        論文摘要:The promising results in replacement of the beta-cell mass have been accomplished by beta-cells implanting. However, the demand for beta-cells is far greater than the supply. The transdifferentiation of stem cells into insulin-secreting cells could potentially provide a new help for beta-cell supplying. To determine whether the myoblast cell line C2C12 could be induced to transdifferentiate into insulin-secreting cells by pancreatic-duodenum homeobox-1 (PDX-1). A myoblast cell line (C2C12) was transfected by the PDX-1 constructing to overexpress PDX-1 protein and then treated with various concentrations of glucagon-like peptide-1 (GLP-1). The Expression of PDX-1 and insulin mRNA was determined by in situ hybridization and the intracellular insulin was determined by immunocytochemistry. The result shows that the PDX-1 transfected cells expressed more insulin and secreted more insulin than the vector transfected cells. We conclude that PDX-1 and GLP-1 might induce myoblasts to transdifferentiate into insulin-secreting cells.
        關鍵詞:GLP-1, glucagon-like peptide 1; ES, embryonic stem; DTZ 遠程下載 論文(免費PDF論文全文)
        發表日期:2005年12月12日
        同行評議:

        目前成體干細胞的可塑性時最為引人注目的,本文的研究進1步進行了檢測,將為糖尿病的治療提供誘人的臨床前景。值得發表。

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        注:同行評議是由特聘的同行專家給出的評審意見,綜合評價是綜合專家對論文各要素的評議得出的數值,以1至5顆星顯示。


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            Transduced adult stem cells into in

            畢業論文


            全部作者:楊川 程樺 李焱 劉丹 王川 嚴勵 傅祖植
            第1作者單位:中山大學附屬第2醫院內分泌科
            論文摘要:The promising results in replacement of the beta-cell mass have been accomplished by beta-cells implanting. However, the demand for beta-cells is far greater than the supply. The transdifferentiation of stem cells into insulin-secreting cells could potentially provide a new help for beta-cell supplying. To determine whether the myoblast cell line C2C12 could be induced to transdifferentiate into insulin-secreting cells by pancreatic-duodenum homeobox-1 (PDX-1). A myoblast cell line (C2C12) was transfected by the PDX-1 constructing to overexpress PDX-1 protein and then treated with various concentrations of glucagon-like peptide-1 (GLP-1). The Expression of PDX-1 and insulin mRNA was determined by in situ hybridization and the intracellular insulin was determined by immunocytochemistry. The result shows that the PDX-1 transfected cells expressed more insulin and secreted more insulin than the vector transfected cells. We conclude that PDX-1 and GLP-1 might induce myoblasts to transdifferentiate into insulin-secreting cells.
            關鍵詞:GLP-1, glucagon-like peptide 1; ES, embryonic stem; DTZ 遠程下載 論文(免費PDF論文全文)
            發表日期:2005年12月12日
            同行評議:

            目前成體干細胞的可塑性時最為引人注目的,本文的研究進1步進行了檢測,將為糖尿病的治療提供誘人的臨床前景。值得發表。

            綜合評價:
            修改稿:
            注:同行評議是由特聘的同行專家給出的評審意見,綜合評價是綜合專家對論文各要素的評議得出的數值,以1至5顆星顯示。