子癇前期患者血清瘦素及可溶性瘦素受體水平變化及臨床意義

子癇前期患者血清瘦素及可溶性瘦素受體水平變化及臨床意義

作者：吳維光，于月成，朱淑平，曹秀琴
【關鍵詞】 妊娠并發癥；高血壓；瘦素；可溶性瘦素受體
【Abstract】 AIM: To investigate the relations between preeclamptic pathogenesis and changes of serum leptin and soluble leptin receptor in preeclampsia, and their clinical significance. METHODS: The peripheral venous blood samples of 40 preeclampsia and 43 normal pregnant women were obtained before and 7 d after operation. The level of leptin was valued by immunoradioassay, and the level of soluble leptin receptor was measured by enzymelinked immunosorbent assay(ELISA). The correlative analysis between the levels of serum leptin and soluble leptin receptor and the blood pressure was performed. RESULTS: The level of leptin before operation was higher than that after operation in all the pregnant women; The level of leptin before operation in preeclampsia was higher than that in normal pregnancy, and the level of soluble leptin receptor before operation in preeclampsia was lower than that in normal pregnancy ; The leptin before operation in preeclampsia was negatively correlated with the soluble leptin receptor, and there were positive correlations between the leptin before operation in preeclampsia and the diastolic pressure or systolic pressure; There were negative correlations between the soluble leptin receptor before operation in preeclampsia and the diastolic pressure or systolic pressure. CONCLUSION: The high level of leptin in preeclampsia may come from placenta, and it may be related to the preeclamptic pathophysiology. The level of leptin or soluble leptin receptor can be a clinical marker to reflect the degree of preeclampsia.
【Keywords】 pregnancy complications; hypertension; leptin; soluble leptin receptor
【摘要】 目的： 探討子癇前期血清瘦素及可溶性瘦素受體水平與子癇前期發病之間的關系及其臨床意義. 方法： 40例子癇前期孕婦及43例正常妊娠孕婦，取術前及術后7 d外周靜脈血，應用放射免疫法檢測瘦素水平，應用ELISA法檢測可溶性瘦素受體水平，并與子癇前期的血壓值進行相關分析. 結果： 子癇前期組和正常妊娠組術后瘦素水平均低于術前；子癇前期組術前瘦素水平高于正常妊娠組，可溶性瘦素受體水平低于正常妊娠組；子癇前期組術前瘦素水平與可溶性瘦素受體水平呈負相關，與收縮壓和舒張壓呈正相關；子癇前期組術前可溶性瘦素受體水平與收縮壓和舒張壓均呈負相關. 結論： 子癇前期升高的瘦素可能來源于胎盤，并可能參與子癇前期的病理生理過程. 血清中瘦素及可溶性瘦素受體水平可作為反映疾病程度的臨床指標.
【關鍵詞】 妊娠并發癥；高血壓；瘦素；可溶性瘦素受體
0引言
瘦素是肥胖（obese）基因的蛋白產物，主要是由脂肪細胞合成和分泌，參與機體的能量代謝. 但近年來研究發現，瘦素與妊娠和生殖調節也存在密切關系［1-2］. 我們觀察了子癇前期患者血清瘦素及可溶性瘦素水平變化，以探討血清瘦素及可溶性瘦素受體與子癇前期之間的關系及其臨床意義.
1對象和方法
1.1對象200401/200511武警醫學院附屬醫院住院手術分娩的

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